CE-marked CT test gives results in 30 minutes

Bath, UK, 02 June 2016. Atlas Genetics Ltd (“Atlas Genetics” or the “Company”), the STI Point-Of-Care (POC) molecular diagnostics company, today notes the major issue of antibiotic resistance for Sexually Transmitted Infections (STIs), as highlighted in the UK Government commissioned anti-microbial resistance report, chaired by Jim O’Neill – ‘Tackling Drug-Resistant Infections Globally’ and recently referenced on the BBC program Newsnight. The O’Neill report recommends that in high income countries health system leaders should ‘support the uptake and use of rapid point-of care diagnostics in primary and secondary care’[1].

The Atlas Genetics io® system, which is CE-marked and cleared for the sale within the European Union for Chlamydia, is the first molecular POC test for a Sexually Transmitted Infection (STI) to enter the market, capable of delivering test results in just 30 minutes. As well as tests for other STIs, Atlas Genetics are developing a range of products, as part of the “Precise” project, in collaboration with St George’s University of London, that will not only detect the presence of STIs but provide invaluable antibiotic resistance information at the same time.

It typically takes patients several days from having a sample taken to receiving their test results. Because of this delay, doctors often treat presumptively and frequently prescribe a strong front-line antibiotic for fear of treatment failure due to resistance, or even the wrong antibiotic based on the patient’s symptoms. The speed of the Atlas Genetics io® system gives doctors the ability to prescribe the appropriate antibiotic immediately.

Dr Chan, Director General of the World Health Organization, said: “Today, antibiotics are rarely prescribed based on a definitive diagnosis. Diagnostics tests can show whether or not an antibiotic is actually needed, and which one. Having rapid, low-cost, and readily available diagnostics is an essential part of the solution to this urgent problem.”[2]

Dr Tariq Sadiq, Chief Investigator of the NIHR invention for innovation (i4i) programme funded “Precise” project at St George’s, University of London, which is developing a POC test for drug resistance with Atlas Genetics commented: “There will be real benefits of using the Atlas Genetics io® as patients will be able to receive the appropriate treatment immediately. In gonorrhoea for example, for the majority of cases there is often no need for injection of very strong front-line antibiotics when more economic antibiotics can effectively treat the problem. Using this more targeted approach means doctors can prescribe the right antibiotic with confidence, reducing the risk of resistance to these newer, stronger antibiotics by sparing their use for when actually needed and potentially generate large savings for healthcare systems.”

John Clarkson, CEO of Atlas Genetics, added: “As highlighted in the O’Neill report, STIs are on the rise and the faster a diagnosis can be made, the faster treatment can be given. This not only benefits the patient but also reduces the burden of unnecessary antibiotic use on the NHS and saves the clinician time and money. We believe that our io® platform will play a critical key role in the future of STI diagnosis.”

New Multiplex test for Sexually Transmitted Infections (STIs)

Bath, UK, 15th March, 2016. Atlas Genetics Ltd (“Atlas Genetics” or the “Company”), the ultra-rapid Point-Of-Care (POC) molecular diagnostics company, today announces that it has been awarded an SBRI grant from Innovate UK to assist in the development of an ultra-rapid POC multiplex STI test measuring the four most commonly occurring pathogens (Chlamydia trachomatis, Neisseria gonorrhoea, Trichomonas vaginalis and Mycoplasma genitalium) in less than 30 minutes.

Atlas Genetics will develop an ultra-rapid POC stratified medicine diagnostic for patients presenting to Sexual Health Clinics with urethritis, which will allow immediate and accurate selection of appropriate and effective antibiotic treatment. Atlas will be collaborating with the Applied Diagnostic Research and Evaluation Unit at St George’s, University of London and Aquarius Population Health. Key elements of this project include cost-effectiveness modelling of introducing this multi-pathogen test, as well as a study on its potential patient impact. The £150,000 grant will be shared between the three organisations.

John Clarkson, CEO of Atlas Genetics, said: “With our Chlamydia test now approved in Europe and our combined Chlamydia/Gonorrhoea test planned for clinical trials later this year, the next step for Atlas is to develop a multiplex test which covers the majority of pathogens for patients entering sexual health clinics. We are very excited to be working with St Georges and Aquarius Population Health on this important project.”

Dr Tariq Sadiq, Chief Investigator at St George’s, University of London, commented: “This is a very exciting development in the STI world. The diagnosis and treatment of sexually transmitted infections has become very challenging for doctors and this new test will allow for patients to have their precise infection identified to enable treatment with the correct antibiotics, immediately after they see a doctor.”

Dr Elisabeth Adams, Managing Director of Aquarius Population Health, added: “We are thrilled to collaborate on this project and develop evidence to demonstrate the likely costs, benefits and cost-effectiveness of an innovative STI test. Results have the potential to positively impact patient care, increase efficiency within the NHS, and improve antimicrobial stewardship.”